Medications play a crucial role in managing acne, particularly for moderate to severe cases. Topical treatments like retinoids and benzoyl peroxide are often first-line therapies. Oral antibiotics can help reduce inflammation and bacterial overgrowth. For severe acne, isotretinoin 20mg (Accutane) can be a game-changer, although it comes with potential side effects and requires careful monitoring. Patients should have a thorough discussion with their dermatologist to understand the benefits and risks of each medication.